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Probiotics usually exert their effects in the gastrointestinal tract, where they may influence the intestinal microbiota. Probiotics can transiently colonize the human gut mucosa in highly individualized patterns, depending on the baseline microbiota, probiotic strain, and gastrointestinal tract region [ 4]. Lactobacillus rhamnosus GG promotes healthy digestion, while the rest of the included stains, such as Lactobacillus gasseri, benefit vaginal and urinary health.
Momin ES, et al. (2023). The effects of probiotics on cholesterol levels in patients with metabolic syndrome: A systematic review. Several meta-analyses have assessed the role of probiotics in patients with IBS [ 42-46]. Most have found that probiotics have a positive, although modest, beneficial effect. For example, a meta-analysis of 23 RCTs in a total of 2,575 patients found that, overall, probiotics reduced the risk that IBS symptoms would persist or not improve by 21% [ 42]. Various species and strains of probiotics had beneficial effects on global IBS symptoms, abdominal pain, bloating, and flatulence scores, but the quality of the studies was low. Some combinations of probiotics were superior to individual strains in this analysis, but no specific combination was superior to another. A second meta-analysis of 15 RCTs in a total of 1,793 patients with IBS found that probiotics reduced overall symptoms and abdominal pain more than placebo after 8 to 10 weeks of therapy; in children, these supplements also improved mucosal barrier function [ 43]. Notably, Lactobacillus acidophilus was present in all of the multistrain supplement studies that reported significant improvements.Kothari D, et al. (2019). Probiotic supplements might not be universally-effective and safe: A review. Another meta-analysis included eight randomized clinical trials with a total of 741 participants from birth to 36 months of age who were treated with Lactobacillus or Bifidobacterium for 4 to 24 weeks. The results also suggested that probiotics containing Lactobacillus might reduce atopic dermatitis symptoms in infants and toddlers, but those containing Bifidobacterium did not [ 16]. The treatment significantly improved symptoms in participants with moderate-to-severe forms of the disease but not in those with mild forms. A Cochrane Review of 39 RCTs of single probiotics and probiotic mixtures for the treatment of eczema in 2,599 participants age 1 to 55 years (most were children) found that probiotic treatment might slightly reduce SCORAD scores. However, the researchers concluded that the differences were not clinically significant and that the current evidence does not support the use of probiotics for eczema treatment [ 17].
Szajewska H, Kolodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther 2015;42:793-801. [ PubMed abstract]Supported by a unique body of UK-based clinical research, the Lab4 live bacteria in ProVen Adult 50 Billion is the most comprehensively studied group of friendly bacteria in the UK. Key features The World Health Organization has defined probiotics as “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host”. In addition to the benefits listed above, some research suggests that probiotic supplements may have the following effects:
Overall, the available evidence indicates that probiotics might reduce some symptoms of IBS. However additional high-quality clinical trials are needed to confirm the specific strain, dose, and duration of treatment required as well as the type of IBS (such as with predominant diarrhea or constipation) that can be treated effectively with probiotics. Hypercholesterolemia Contains Lab4 friendly bacteria with Lactobacillus gasseri, which forms a normal part of the vaginal flora Because effects of probiotics can be specific to certain probiotic species and strains, recommendations for their use in the clinic or in research studies need to be species and strain specific [ 3, 5, 6]. Furthermore, pooling data from studies of different types of probiotics can result in misleading conclusions about their efficacy and safety. Sources of Probiotics Food ProVen Women’s Lactobacillus & Bifidus with Cranberry contains three Lactobacillus strains – two Lactobacillus acidophilus strains and Lactobacillus gasseri, which is a key part of the vaginal flora. Probiotics are also available in supplement form. These supplements contain high doses of either a single probiotic strain or multiple probiotic strains.Perna S, et al. (2021). Is probiotic supplementation useful for the management of body weight and other anthropometric measures in adults affected by overweight and obesity with metabolic related diseases? A systematic review and meta-analysis. Though more research in humans is needed, some studies suggest that phages, including the phages in Culturelle Women’s 4-in-1 Protection, could be used as an alternative treatment for UTIs, including antibiotic-resistant UTIs. Taking friendly bacteria such as Acidophilus and Bifidus alongside and following antibiotics may help to maintain a balanced microbiota. Multi-strain ultra-high-strength live bacteria The gut microbiota play an important role in nutrient and energy extraction from food. Research in mice suggests that the gut microbiota affect not only use of energy from the diet, but also energy expenditure and storage within the host [ 58]. Whether these effects translate to humans is unknown. Makrgeorgou A, Leonardi-Bee J, Bath-Hextall FJ, Murrell DF, Tang ML, Roberts A, et al. Probiotics for treating eczema. Cochrane Database Syst Rev 2018;11:CD006135. [ PubMed abstract]
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